PROBLEM TO BE SOLVED: To provide a tissue fastening tool certainly restored to a predetermined shape, an applicator for suitably indwelling the tool within a body, and a tissue fastening device.SOLUTION: The tissue fastening device is equipped with: the tissue fastening tool consisting of a wire material wound in a coil shape having a first tissue fixing part hooked with first bio-tissue and a second tissue fixing part hooked with second bio-tissue and the applicator having a tubular puncturing tool for extending the tissue fastening tool to internally insert it, the fastening tool pusher inserted in the puncturing tool at its leading end part and pushing out the tissue fastening tool inserted in the puncturing tool from the leading end of the puncturing tool at the time of advance, and a rotary mechanism for rotating the puncturing tool when the fastening tool pusher is advanced.COPYRIGHT: (C)2010,JPO&INPIT【課題】所定形状に確実に復元される組織締付具、この組織締付具を好適に体内に留置するためのアプリケータ、および組織締付装置を提供すること。【解決手段】この組織締付装置は、第一の生体組織に掛止する第一の組織固定部と、第二の生体組織に掛止する第二の組織固定部とを有するコイル状に巻かれた線材からなる組織締付具と、前記組織締付具を引き延ばして内部に挿入する管状の刺入具と、先端が前記刺入具に挿入され、前進するときに前記刺入具に挿入した前記組織締付具を前記刺入具の先端から押し出す締付具プッシャと、前記締付具プッシャが前進するときに前記刺入具を回転させる回転機構とを有するアプリケータと、を備える。【選択図】図1