CHILDREN'S HOSPITAL MEDICAL CENTER;CHILDRENS HOSPITAL MEDICAL CENTER
发明人:
WELLS, JAMES M.,MUNERA, JORGE ORLANDO
申请号：
CA3045145
公开号：
CA3045145A1
申请日:
2017.12.05
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed herein are methods for the in vitro differentiation of a precursor cell into definitive endoderm, which may further be differentiated into a human colonic organoid (HCO), via modulation of signaling pathways. Further disclosed are HCOs and methods of using HCOs, which may be used, for example, for the HCOs may be used to determine the efficacy and/or toxicity of a potential therapeutic agent for a disease selected from colitis, colon cancer, polyposis syndromes, and/or irritable bowel syndrome.
