The present invention describes pharmaceutical compositions of nasal spray for systemic delivery of drugs. The pharmaceutical nasal spray composition which comprises nanosuspension phase which contains drug in form of nanosuspension which is stabilized either by surfactants or polymers or their combination and in-situ gelling phase which contains in-situ gelling polymer with other ingredients pH modifier, preservative etc. These two phases are mixed to form uniform dispersion of nanosuspension in in- situ gelling phase.
