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Compositions and methods for inducing nanoparticle-mediated microvascular embolization of tumors
专利权人:
LLC;Vindico Nanobiotechnology
发明人:
Ghoroghchian, P. Peter
申请号:
AU2015301014
公开号:
AU2015301014A1
申请日:
2015.08.06
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
Nanoparticle mediated microvascular embolization (NME) of tumor tissue may occur after systemic administration of PEM, leading to widespread shutdown of vascular flow, hemorrhage, and necrosis. PEM constructs are developed that incorporate large amounts of iron-containing protein, possess high oxygen affinities, and demonstrate delayed nitric oxide binding. Such properties induce selective NME of tumors after extravasation, and will likely enhance the effect of VEGFR TKIs and/or mTOR inhibitors.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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