Julien Papillon;Qi-Ying Hu;Gary Michael Ksander;Christopher Adams
发明人:
Christopher Adams,Qi-Ying Hu,Gary Michael Ksander,Julien Papillon
申请号：
US12519697
公开号：
US08436035B2
申请日:
2007.12.14
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides a compound of formula I:said compound is inhibitor of aldosterone synthase (CYP11B2), and/or 11 beta-hydroxylase (CYP11B1), and/or aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase, aromatase, or CYP11B1. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, increased formation of collagen, fibrosis and remodeling following hypertension and endothelial dysfunction. Finally, the present invention also provides a pharmaceutical composition.
