As for this invention, pertaining to the method in order to produce the human monoclonal antibody from the immunity incomplete non human animal, the said method, the immunity transplantation non human animal (the reconstruction animal) in order to produce the new life immunity incomplete non human animal the human fetus liver trunk cell (the FL cell) with the stage which is made to contact, continuously the said antibody includes the stage which is isolated from stage, and the said antibody production cell which collect the human cell which produces the human antibody from stage and the said reconstruction animal which make the said reconstruction animal contact with the antigen for the said antigen.本発明は、免疫不全非ヒト動物からヒトモノクローナル抗体を産生するための方法に関連し、該方法は、免疫移植非ヒト動物(再構成動物)を作製するために新生免疫不全非ヒト動物をヒト胎児肝臓幹細胞(FL細胞)と接触させる段階、続いて該再構成動物を抗原と接触させる段階、該再構成動物から該抗原に対するヒト抗体を産生するヒト細胞を収集する段階、および該抗体産生細胞から該抗体を単離する段階を含む。
