DIAGNOSTIC AND THERAPEUTIC POTENTIAL OF HLA-E MONOSPECIFIC MONOCLONAL IgG ANTIBODIES DIRECTED AGAINST TUMOR CELL SURFACE AND SOLUBLE HLA-E

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专利权人:

THE TERASAKI FAMILY FOUNDATION

发明人:

RAVINDRANATH, MEPUR H.,TERASAKI, PAUL I.

申请号：

EP13813710

公开号：

EP2870179A4

申请日:

2013.07.01

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Provided herein are compositions comprising purified antibodies and fragments thereof that are specifically immunoreactive to only human leukocyte antigen E (HLA-E) but not to other HLA Ia and HLA-Ib alleles. Also provided are methods of their making and diagnostic and therapeutic applications. The monospecific HLA-E antibodies are highly specific and can be used for diagnosing or localizing the presence of HLA-E on normal or diseased cells or tissues. The monospecific HLA-E antibodies can also be used for cancer therapies, likely through regulation of the CD94/NKG2a on Cytotoxic and/or Natural Killer T cells.

来源网站：

中国工程科技知识中心

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