THERE IS DISCLOSED A CATHETER ASSEMBLY (200) COMPRISING: A CATHETER HUB (14) COMPRISING A HOUSING COMPRISING AN EXTERIOR SURFACE (20) AND AN INTERIOR SURFACE (22) DEFINING A CAVITY (24); A CATHETER TUBE (12) ATTACHED TO THE CATHETER HUB (14) AND EXTENDING DISTALLY OF THE CATHETER HUB (14); A NEEDLE HUB (18) COMPRISING A HOUSING; A NEEDLE (16) HAVING A NEEDLE TIP (72) ATTACHED TO THE NEEDLE HUB (18) AND PROJECTING DISTALLY OF THE NEEDLE HUB (18) AND INTO THE CATHETER TUBE (12); A VALVE (46) FOR LIMITING BLOOD BACKFLOW POSITIONED IN THE INTERIOR CAVITY (24) OF THE CATHETER HUB (14); A VALVE OPENER (48) FOR OPENING THE VALVE (46) POSITIONED PROXIMALLY OF THE VALVE (46); AND A PASSIVE OR SELF-ACTIVATING DEVICE FOR COVERING THE NEEDLE (16), COMPRISING: A THIRD HOUSING (204); A TIP PROTECTOR (202) ACCOMMODATED WITHIN THE THIRD HOUSING (204) FOR BLOCKING THE NEEDLE TIP (72); AND AN ARM (210) EXTENDING FROM THE THIRD HOUSING (204) TO ENGAGE THE CATHETER HUB (14). (FIG. 13)