INHIBITION SELECTIVE DU COMPLEXE D'ATTAQUE MEMBRANAIRE DU COMPLEMENT ET DE LA C3 CONVERTASE PAR DES COMPOSANTS A FAIBLE POIDS MOLECULAIRE DU COMPLEXE SYNTHETIQUE D'ACIDE PARAROSOLIQUE TRICARBOXYLIQUE
MCGEER, PATRICK L.,LEE MOONHEE,SCHWAB, CLAUDIA,GUO, JIAN-PING
申请号：
CA2878734
公开号：
CA2878734A1
申请日:
2012.07.13
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Selective inhibition of the membrane attack complex of complement in a mammalian species, preferably human, with components of the aurin tricarboxylic acid complex of less than 1 kilodalton in molecular weight. Preferred inhibitors are aurin tricarboxylic acid, aurin quadracarboxylic acid and aurin hexacarboxylic acid. Preferred disease to be treated by elective inhibition of the membrane attack complex of complement are age-related macular degeneration, Alzheimer's disease, atherosclerosis, rheumatoid arthritis, paroxysmal nocturnal hemoglobinemia, malaria infection and multiple sclerosis.
