Exemplary embodiments for self-aligning a sensor array with respect to blood vessel of a user comprise: determining an optimal sensor in a sensor array comprising an array of discrete sensors arranged on a band such that the sensor array straddles or otherwise addresses a blood vessel or other targeted area of a user by activating each of the discrete sensors to generate respective signals designating as the optimal discrete sensor a particular discrete sensor producing a highest signal-to-noise ratio and using the optimal sensor to collect physiological data of the user.
