Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: ； ； ； and wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.本發明係關於具有藥物及生物作用性質之化合物、其醫藥組合物及使用方法。特定而言，提供具有獨特抗病毒活性之C-3環烯三萜類化合物作為HIV成熟抑制劑，此等化合物如由式I、II、III及IV之化合物所示：；；；及其中X可為C4-8環烷基、C4-8環烯基、C4-9螺環烷基、C4-9螺環烯基、C4-8氧雜環烷基、C4-8二氧雜環烷基、C6-8氧雜環烯基、C6-8二氧雜環烯基、C6-9氧雜螺環烷基或C6-9氧雜螺環烯基環。此等化合物適用於治療HIV及AIDS。
