The present invention provides for antibodies that bind to Notch1. The present disclosure also provides methods of making the antibodies, pharmaceutical compositions comprising these antibodies and methods of treating disorders with the antibodies and pharmaceutical compositions.本發明提供與缺口1結合之抗體類。本發明亦提供製備該等抗體之方法、包含該等抗體之醫藥組成物、及使用該等抗體及醫藥組成物以治療疾病之方法。