A surgical isolation drape comprises a medical-grade flexible container body including an inside surface, a first end that is normally open, thus defining a first mouth, and a second end opposite the first end that is normally open, thus defining a second mouth. The surgical isolation drape also includes a first closure mechanism to close the first mouth. For instance, the first closure mechanism can include a first channel inside of the container body proximate the first mouth. A first closure line passes through the first channel, such that access to the first closure line is provided from a position inside the container body. The surgical isolation drape still further includes a first locking mechanism that engages the first closure line, such that access to the first locking mechanism is provided from a position inside the body.
