Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy

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专利权人:

Iovance Biotherapeutics; Inc.

发明人:

CHARTIER-COURTAUD, Cecile,RITTHIPICHAI, Krit

申请号：

AU2019257749

公开号：

AU2019257749A1

申请日:

2019.04.26

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. The methods may comprise gene-editing at least a portion of the TILs to enhance their therapeutic efficacy. Such TILs find use in therapeutic treatment regimens.

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中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/