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METHOD AND FORMULATION FOR REDUCING AGGREGATION OF A MACROMOLECULE UNDER PHYSIOLOGICAL CONDITIONS
专利权人:
GENENTECH INC
发明人:
LOBO BRIAN,LO SABRINA,WANG YUCHANG JOHN,WONG RITA L
申请号:
ZA201103006
公开号:
ZA201103006B
申请日:
2011.04.20
申请国别(地区):
ZA
年份:
2012
代理人:
摘要:
The invention provides a method for reducing aggregation and inhibiting flocculation of a macromolecule, such as a protein, under physiological conditions, by the addition of certain cyclodextrins (CDs). The invention also provides a method to minimize inflammation at the injection site during subcutaneous administration of a macromolecule and pharmaceutical formulations for such administration. Further the invention provides methods of treating a CD20 positive cancer or an autoimmune disease, comprising administering a humanized anti-CD20 antibody in a pharmaceutical formulation of the invention. The invention further provides an in vitro dialysis method to evaluate the ability of an excipient to reduce aggregation of an antibody or other macromolecule under physiological conditions.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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