Ramesh NARAYANAN,Duane D. MILLER,Thamarai PONNUSAMY,Dong-Jin Hwang,Jayaprakash PAGADALA,Charles B. DUKE,Christopher C. COSS,James T. DALTON,Yali HE
申请号:
US15135334
公开号:
US20170095446A1
申请日:
2016.04.21
申请国别(地区):
US
年份:
2017
代理人:
摘要:
This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyper androgenic dermal diseases, Kennedys disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.