THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;Dana-Farber Cancer Institute, Inc.
发明人:
Wayne A. Marasco,Jianhua Sui,Quan Zhu,De-Kuan Chang,Thomas S. Kupper
申请号：
US16222342
公开号：
US20190276544A1
申请日:
2018.12.17
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides affinity matured humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to the chemokine receptor CCR4. This antibody is derived from mAb 1567 and recognizes the same epitope. Binding of the antibodies disclosed herein to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells.
