The present invention provides a composition for reducing D-galactose induced cranial neuron damage, which at least contains ergothioneine (EGT). The applied ratio is that the amount of EGT applied for each kg of individual is less than 2 mg. Preferably, the composition and the melatonin may have the synergetic effect, and the applied ratio is that the amount of melatonin applied for each kg of individual is less than 10 mg. Preferably, the applied ratio of EGT in the composition is that the amount of EGT applied for each kg of individual is greater than 0.5 mg. In summary, the present invention utilizes EGT to reduce D-galactose induced cranial neuron damage and achieves the purpose of cranial neuron protection.本發明係一種減少D-半乳糖誘導腦部神經細胞傷害之組成物,該組成物至少包含麥角硫因,所施用的比例為每kg個體施用麥角硫因小於2 mg。較佳地,其中該組成物與退黑激素有協同作用,所施用的比例為每kg個體施用褪黑激素小於10 mg。較佳地,其中組成物之麥角硫因所施用的比例為每kg個體施用麥角硫因在大於0.5mg。藉上所述,將麥角硫因利用以減少D-半乳糖誘導腦部神經細胞傷害,並達到保護神經細胞之目的。
