An application of Gynura divaricata in preparing medicine or health food for treating hepatitis. A high-dose group of a Gynura divaricata alcohol extract and a Gynura divaricata aqueous extract can obviously inhibit a mouse acute liver injury caused by carbon tetrachloride, reduce serum glutamic pyruvic transaminase and glutamic oxalacetic transaminase, and alleviate degeneration and necrosis of hepatocyte