HORI HITOSHI,堀 均,TOKUNAGA HIKO,徳永 彦,TAKAHASHI MASAO,高橋 雅夫
申请号：
JP2018072734
公开号：
JP2019163229A
申请日:
2018.03.19
申请国别(地区):
JP
年份:
2019
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide a drug transport (delivery) material with excellent specific accumulation property to tumor cells or cancer cells which is produced by chemically bonding oligosaccharide and oligopeptide, which are excellent in specific binding properties to tumor cells or cancer cells and can be easily and simply produced, to boron isotope nano-silica particles, for boron neutron capture therapy (BNCT).SOLUTION: Boron isotopes are first chemically bonded to nano-silica particles, and oligosaccharide and oligopeptide are further bonded while considering selectivity and accumulation property to various types of tumor cells or cancer cells, and BNCT is complete.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2019,JPO&INPIT【課題】腫瘍細胞、癌細胞への特異的な結合性に優れ、簡便、簡易に製造できるオリゴ糖、オリゴペプチドをホウ素同位体ナノシリカ粒子に化学結合することで、腫瘍細胞、癌細胞への特異的な集積性に優れた薬物輸送（送達）を材料として中性子捕捉療法（ＢＮＣＴ）に提供する。【解決手段】ナノシリカ粒子に先ずホウ素同位体を化学結合させ、又種々の腫瘍細胞、癌細胞への選択性、集積性を考慮しオリゴ糖、オリゴペプチド更に結合させＢＮＣＴができる。【選択図】図１
