The present invention provides uses and methods of using a sema3E polypeptide and a sema3e polynucleotide encoding a sema3E polypeptide. The methods include decreasing airway remodeling in a subject, treating asthma in a subject, treating a subject having, or at risk of having, acute asthma, and reducing inflammation of a subject's airway. The methods also include evaluating treatment options for a subject having asthma and diagnosing whether a subject has asthma.
