Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula Iand the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.揭露腈衍生物及包含腈衍生物之藥學組成物。此藥學組成物包含化學式I之化合物及此化合物之藥學上可接受之鹽。亦揭露用於製備此化合物之方法，用於製備此化合物之中間產物，及此化合物於治療高增殖疾病、發炎疾病，及病毒與細菌感染及誘發癌細胞之細胞凋亡之用途。
