THE UNITED STATES OF AMERICA; as represented by the Secretary; Department of Health and Human Services
发明人:
Rachel R. Caspi,Wai Po Chong,Reiko Yamane,Mary Mattapallil
申请号：
US15957019
公开号：
US10512671B2
申请日:
2018.04.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods are provided for treating ocular surface inflammation and/or uveitis in a subject. The methods can include selecting a subject with uveitis and/or ocular surface disease. The methods can then include administering to the subject a therapeutically effective amount of an interleukin 24 (IL-24) polypeptide or nucleic acid encoding the IL-24 polypeptide. In some examples, the administered IL-24 polypeptide suppresses production of effector cytokines by Th17 cells. A pharmaceutical composition is further provided here that includes an IL-24 polypeptide or nucleic acid encoding the polypeptide. In some examples, the IL-24 polypeptide is a variant of IL-24 or an Fc fusion protein that includes IL-24. The pharmaceutical composition can be used in any of the methods provided herein to treat ocular surface inflammation and/or uveitis.
