PROBLEM TO BE SOLVED: To provide an anticancer agent acting on Hippo route.SOLUTION: The present invention provides a preventive or therapeutic agent for cancer having abnormality in Hippo route, comprising ivermectin or milbemycin D as an active ingredient.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】Hippo経路に作用する抗癌剤の提供。【解決手段】イベルメクチン又はミルベマイシンDを有効成分とする、Hippo経路に異常を有する癌の予防又は治療剤。【選択図】なし