RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
发明人:
GOODMAN, Steven David,BAKALETZ, Lauren O.
申请号：
WO2018US22508
公开号：
WO2018170178(A9)
申请日:
2018.03.14
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more modified HMG-box 1 domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system.
