3-IMIDAZOLIL-INDOS FOR TREATMENT OF PROLIFERATIVE DISEASES

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专利权人:

NOVARTIS AG

发明人:

ANDREAS BOETTCHER,NICOLE BUSCHMANN,PASCAL FURET,JEAN-MARC GROELL,JOERG KALLEN,JOANNA HERGOVICH LISZTWAN,KEIICHI MAUYA,LORENZ MAYR,ANDREA VAUPEL

申请号：

BRPI0810082

公开号：

BRPI0810082A2

申请日:

2008.03.27

申请国别(地区):

BR

年份:

2014

代理人:

摘要：

The invention relates to 3-heterocyclyl indolyl compounds of formula I capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively: wherein R1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/