The present invention includes an apparatus, system and method for detection of tissues, e.g., a cancer, by optical biopsy comprising: a motorized computer-controlled probe holder a needle-like probe connected to and controlled by the motorized computer-controlled probe holder, the probe comprising an optical and an ultrasound detector and one or more detector units capable of a broadband light reflectance spectroscopy, an auto fluorescence lifetime measurement, and auto fluorescence spectroscopy measurement.
