methods for treating an autoimmune disease or inflammatory disorder in a human subject, for treating multiple sclerosis in an individual, and for identifying antibodies, isolated human, humanized or chimeric antibody or antigen binding fragment thereof, and, isolated connection.
HONGTAO LU,JINGWU ZANG,LIXIN LI,PING TSUI,STEWART LEUNG,XUEBIN LIU
申请号：
BRPI0916945
公开号：
BRPI0916945A2
申请日:
2009.08.07
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention provides novel methods of treatment of multiple sclerosis and other autoimmune diseases or inflammatory disorders, and antagonists, including isolated binding proteins for use in the novel methods. There is provided a method of treating multiple sclerosis comprising the neutralization of the biological activity of IL-7 by binding to CD127 or IL-7. The isolated binding proteins may also neutralize the biological activity of TSLP.
