The inventors of the present disclosure recognized that, surprisingly, the antimicrobial treatments used on cellulosic sponges do not work in hydrophilic polyurethane sponges. As such, the inventors of the present disclosure discovered a need for an antimicrobial treatment for use on hydrophilic polyurethane foam sponges. The present inventors invented one antimicrobial composition for use on hydrophilic polyurethane foam sponges including an acetate salt solution humectant. The present inventors invented another antimicrobial composition for use on hydrophilic polyurethane foam sponges including a non-halogen humectant comprising a salt solution having a pH between about 3 and 10 and a water activity of less than 0.9 at 25℃.本揭露之發明人驚訝地認知到,在纖維素海綿上使用的抗微生物處理在親水性聚胺甲酸酯海綿中不起作用。因此,本揭露之發明人發現需要在親水性聚胺甲酸酯發泡體海綿上使用抗微生物處理。本發明人發明了一種用於親水性聚胺甲酸酯發泡體海綿的抗微生物組成物,其包括醋酸鹽溶液保濕劑。本發明人發明了另一種用於親水性聚胺甲酸酯發泡體海綿的抗微生物組成物,其包括非鹵素保濕劑,該非鹵素保濕劑包含具有介於約3及10之間的pH及在25℃下小於0.9的水活性的鹽溶液。