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ПРОФИЛАКТИКА И ЛЕЧЕНИЕ ПАТОЛОГИЧЕСКИХ СОСТОЯНИЙ ГЛАЗ, ВЫЗВАННЫХ КОМПЛЕМЕНТОМ
专利权人:
ДЖЕНЕНТЕК; ИНК. (US)
发明人:
ХАСС Филип (US),ИНЬ Цзяньпин (US),КАТШКЕ Кеннет Мл. (US),СТЕФФЕК Миках (US),ВИСМАНН Кристиан (US),ВАН ЛОКЕРЕН КАМПАГНЕ Менно (US)
申请号:
RU2014113046/10
公开号:
RU2014113046A
申请日:
2014.04.03
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method for preventing or treating pathological conditions of the eye caused by the complement, which is administering to a subject in need thereof an effective amount of an antagonist of factor D.2. The method of claim. 1, wherein said subject is mlekopitayuschim.3. The method of claim. 2, wherein said subject is chelovekom.4. The method of claim. 3 wherein said Factor D antagonist is selected from the group consisting of anti-Factor D antibodies and fragments thereof, binding polypeptides, peptides and non-peptide small molecules prirody.5. A method according to claim. 4, wherein said Factor D antagonist is an antibody or fragment antitela.6. The method of claim. 5, where the antibody binds to the active site of factor D.7. The method of claim. 5, wherein said antibody binds to an epitope comprising residues of the active site of factor D.8. The method of claim. 5, wherein said antibody is selected from the group consisting of antibodies 20D12, 31A9, 25A1 and 32H12, and their variantov.9. The method of claim. 5, wherein said antibody binds essentially the same epitope as an antibody 20D12.10. . A method according to claim 5, wherein said antibody comprises the CDR sequences of the heavy and / or light chain of antibody 20D12 (SEQ ID NO: 1 and 2) .11. The method of claim. 5, wherein said antibody is soboychelovecheskoe, humanized or chimeric antitelo.12. The method of claim. 5, where an antibody said fragment is selected from the group consisting of Fab fragments, Fab , F (ab), scFv, (scFv), dAb, complementarity determining region (CDR), linear antibodies, single-chain antibody molecules, Minitel, diabodies and multispecific antibodies formed from antitel.13 fragments. The method of claim. 12 wherein said fragment is an antibody fragment Fab, Fab , F (ab), scFv1. Способ профилактики или лечения патологического состояния глаз, вызванного комплементом, представляющий собой введение субъекту, нуждающемуся в этом, эффективного количества антагониста фактора D.2. Сп
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