John Salogiannis,Michael E. Greenberg,Seth S. Margolis
申请号：
US14615083
公开号：
US09541546B2
申请日:
2015.02.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides methods of screening a compound that can increase spine/excitatory synapse formation and/or numbers. The compound is identified by contacting Ephexin5 with a test compound and selecting the compounds that inhibit Rho GEF activity of Ephexin5. Additionally, the invention also provides methods for increasing spine/excitatory synapse formation and/or numbers by contacting a neuron with an Ephexin5 inhibitor.
