The Board Of Trustees Of The Leland Stanford Junior University
发明人:
BOGYO, Matthew S.,VERDOES, Martijn,OFORI, Leslie,WITHANA, Nimali P.
申请号：
EP16740869
公开号：
EP3247802A4
申请日:
2016.01.22
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.
