Di YU,Magnus ESSAND,Chuan JIN,Mohanraj RAMACHANDRAN,Jing MA
申请号：
US16333453
公开号：
US20190209615A1
申请日:
2016.09.15
申请国别(地区):
US
年份:
2019
代理人:
摘要：
T-cells useful in T-cell immunotherapy comprise a CAR, TCR and/or nucleic acid sequence(s) encoding a CAR and/or a TCR. The T-cells also comprise HP-NAP, an immunological equivalent fragment thereof and/or nucleic acid sequence(s) encoding HAP-NAP and/or an immunological equivalent fragment thereof. The T-cells have improved effects in immunotherapy including improved cytotoxicity, stimulation of chemokine and cytokine secretion, promoting dendritic cell maturation and recruitment and activation of innate immune cells.
