BETT, ANDREW,COLLER, BETH-ANN GRISWOLD,DHANASEKARAN, GOVINDARAJAN,CHINTALA, RAMESH, V.
申请号：
PH12015502666
公开号：
PH12015502666A1
申请日:
2015.11.27
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
The present invention relates to dengue virus vaccine compositions comprising a first and a second dengue vaccine, wherein the first dengue vaccine is a live, attenuated dengue vaccine and the second dengue vaccine is a recombinant dengue subunit vaccine or an inactivated dengue vaccine wherein the live attenuated dengue vaccine comprises at least one live, attenuated dengue virus or at least one live attenuated chimeric flavivirus. The dengue virus vaccine compositions of the invention may further comprise one or more adjuvants. In preferred embodiments of the invention, the first and the second dengue vaccine are tetravalent. The invention also relates to methods of using the dengue virus vaccine compositions of the invention to treat or prevent dengue infection, or to prevent, ameliorate, or delay the onset or progression of the clinical manifestations thereof.
