As a herbal remedy to asthma the invention is composed of weighed proportional mixture of Sunnut honey and powder of grounded seeds of Solanum dubium.Phytochemical analysis was performed on the crude extracts of the seeds, honey and their combination. Separation and isolation of active compounds from the methanolic extract of combination was carried out using bioassay-guided fractionation. Fractionation and isolation of the active ingredients of the methanolic extract were performed by Column Chromatography (monitored by TLC and PTLC). Nuclear magnetic resonance (NMR), mass spectrometry (MS), ultraviolet (UV) and infrared (IR) spectrometry were used for structure elucidation of the isolated compounds.The in-vivo experiments implemented are to assess the toxicological study of the crude and methanolic extracts of the combination, honey and the seeds on (96) Wister Albino rats using the acute toxicity (LD50 percentage) done on 7-days and sub-chronic for 28 days. The results revealed that there is no acute or sub-chronic toxicity displayed by the different concentrations of the extracts.The method of Carrageenan induced paw oedem in (162) Wister Rats was done to evaluate the anti-inflammatory effects of aqueous crude extract of S. dubuim seeds, honey and combination. The results showed that all ingredients were found to have a significant anti inflammatory activity on paw edema volume. Also the result of methanolic extracts showed a significant inhibition of inflammation. The results of the anti-inflammatory activity of the fractions of methanolic extract, five fractions showed a significant inhibition of inflammation over the other alcoholic fraction extracts. Also all fractions decreased rat paw edema.The bronchodilator activities of aqueous crude extract of the three ingredients was done using in vitro studies on isolated tracheal preparations of Guinea pigs and Guinea pigs pattern of allergic asthma setup experiment. The results of bronchodilator activities, the an
