A Smart Medication Adherence Refrigeration Tray (SMART) along with method of use to assist with self-management of medication treatment by patients. The SMART medication tray accepts a plurality of medication filled containers of various sizes along with individual storage compartments for each container. Each medication storage compartment uses an embedded scale mechanism to monitor the amount of medication being taken by the patient and to assist with the medication adherence compliance. A series of optical sensors are utilized to detect when medication bottles are placed on the storage compartment as well as when they are being removed. Medication tray utilizes wireless technology to interactively communicate with outside computing devices to receive medication prescription and assist with the adherence process.
