The present invention discloses: (i) a novel, lactone-stable, ~flipped~ E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof； (ii) methods of synthesis of said novel, lactone-stable, ~flipped~ E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof； (iii) pharmaceutically-acceptable formulations comprising said novel, lactone-stable, ~flipped~ E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more additional chemotherapeutic agents； (iv) methods of administration of said novel, lactone-stable, ~flipped~ E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more additional chemotherapeutic agents, to subjects in need thereof； and (v) devices for the administration of said novel, lactone-stable, ~flipped~ E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more chemotherapeutic agents, to subjects in need thereof.
