FORMULATIONS COMPRISING A MEGLUMINE SALT OF THE METAL COMPLEX GD-DOTA

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专利权人:

发明人:

MEIJER ANDREAS RICHARD,THANING MIKKEL JACOB

申请号：

IN201747022516

公开号：

IN201747022516A

申请日:

2017.06.27

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

The present invention relates to a method of preparation of formulations of gadolinium metal complexes of the macrocyclic chelator DOTA as a meglumine salt which further comprise a small excess of free DOTA. The method uses controlled conditions such that excess gadolinium is present as a precipitate of gadolinium oxide with filtration to remove the excess prior to the addition of a defined excess of DOTA chelator. Also provided is a method of preparation ofMRI contrast agents based on Gd DOTA.

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中国工程科技知识中心

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http://www.ckcest.cn/home/