The United States of America, as represented by the Secretary, Department of Health and Human;Institute for Research in Biomedicine
发明人:
Peter Kwong,Michael Gordon Joyce,Baoshan Zhang,Yongping Yang,Peter Collins,Ursula Buchholz,Davide Corti,Antonio Lanzavecchia,Guillaume Stewart-Jones
申请号：
US15539640
公开号：
US20180008697A1
申请日:
2015.12.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
