The present invention provides for drug-delivery systems and compositions comprising zotarolimus and paclitaxel, or derivatives, prodrugs or salts thereof, as well as methods of treatment using such systems and compositions, wherein the drugs complement each other in effect and/or activity. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and drug-delivery systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.La présente invention concerne des systèmes dadministration de médicament et des compositions comprenant du Zotarolimus et du Paclitaxel, ou des dérivés, promédicaments ou sels de ceux-ci ainsi que des procédés de traitement utilisant de tels systèmes et de telles compositions, caractérisés en ce que les médicaments se complètent lun lautre en termes deffet et/ou dactivité. Linvention concerne des dispositifs médicaux qui comprennent des structures support qui comprennent au moins un véhicule ou excipient acceptable du point de vue pharmaceutique, lequel véhicule ou excipient peut comprendre un ou plusieurs agents ou substances
