Methods and compositions for treating and preventing intestinal injury are described. In particular, methods and delayed-release enteric coated compositions of glycerophosphate salts for treating and preventing an intestinal injury, such as exercise-induced intestinal injury, intestinal injury induced or aggravated by ingestion of a nonsteroidal anti-inflammatory drug (NSAID), or exercise-induced intestinal injury aggravated by an NSAID, are described. Orally or nasally administering a therapeutically effective amount of a glycerophosphate salt, particularly calcium glycerophosphate, to a subject engaging in exercise, particularly a subject engaging in exercise and ingesting a NSAID for the treatment or prevention of musculoskeletal pain resulting from exercise, reduces exercise-induced intestinal injury, particularly exercise- induced intestinal injury aggravated by the NSAID. A method of increasing tight junction integrity in a subject in need thereof is also described. The method involves administering to the subject a composition comprising an effective amount of glycerophosphate, such as calcium glycerophosphate. A method of treating or preventing a disease related to tight junction dysfunction, such as an inflammatory disease or a cancer, is also described.Se describen métodos y composiciones para tratar y prevenir lesión intestinal en particular se describen métodos y composiciones revestidas entéricas de liberación retrasada de sales de glicerofosfato para tratar y prevenir una lesión intestinal, como lesión intestinal inducida por el ejercicio, lesión intestinal inducida o agravada por ingestión de fármacos antiinflamatorios no esteroideos (NSAID) o lesión intestinal inducida por el ejercicio agravada por un NSAID la administración oral o nasal de una cantidad terapéuticamente efectiva de una sal de glicerofosfato, particularmente glicerofosfato de calcio, a un sujeto que realiza un ejercicio, particularmente un sujeto que realiza ejercicio e ingiere un NSA
