The present invention relates to formula (I) therapeutic agents or its pharmaceutical salt as atypical antipsychotic agents. They can be used for treating nerve related with dopamine D 2 and serotonin 5-HT2A neurotransmission dysfunctions and phrenoblabia, wherein R1 is unsubstituted or by a fluorine-substituted C1-6 alkyl of 1-6, and wherein the hydroxyl on R1 and ring is connected on same carbon atom.