The present invention discloses a desensitizing toothpaste. Based on the total weight of the desensitizing toothpaste, the desensitizing toothpaste comprises: from 5% to 40% by weight of DP-bioglass from 1% to 5% by weight of thickening agents from 25% to 35% by weight of humectant and from 1% to 5% by weight of surfactant, wherein the DP-bioglass comprises: 8.4% of Na2O, 40.6% of CaO, 39% of SiO2, and 12% of P2O5based on the total weight of the DP-bioglass. With the implementation of the present invention, the indication of dentin hypersensitivity can be greatly relieved.本發明係為一種抗敏感牙膏,其包括:以抗敏感牙膏之總重計,介於5%至40%之間之DP生醫玻璃;介於1%至5%之間之增稠劑;介於25%至35%之間之保濕劑;以及介於1%至5%之間之界面活性劑,其中DP生醫玻璃含有以DP生醫玻璃總重量計,8.4%之Na2O、40.6%之CaO、39%之SiO2及12%之P2O5。藉由本發明之實施,牙齒敏感的症狀可以有效地被改善。