The present invention provides a composition for enhancing cell engraftment and homing properties, containing platelet-rich plasma (PRP) as an active ingredient. The present invention provides a method for improving cell engraftment and homing properties, comprising the step of treating in vitro isolated cells with a composition containing PRP as an active ingredient. According to the present invention, when a cell to be transplanted or a region to which cells are transplanted is treated with PRP, or a cell to be transplanted is mixed with PRP, transplantation to an in vivo region is carried out, thereby increasing cell engraftment in a transplanted region and increasing cell homing from a transplanted region to a damaged region.
