The present invention relates to a recombinant deoxyribonucleic acid vaccine comprising the coding sequence for the ectodomain of the glycoprotein G of the viral haemorrhagic septicaemia virus (VHSV), the coding sequence for a signal peptide of pleurocidin of Limanda limanda and the promoter of β-actin of carp for the treatment and / or prevention of viral haemorrhagic septicaemia caused by VHSV. The vaccine of the invention provides protection when administered both intramuscularly and intraperitoneally.
