A medical shoe having an overmolding layer with a non-uniform density is provided. The medical shoe may include a midsole configured to support a foot, and a frame surrounding the midsole. The midsole may include a foot receiving portion forming a substantially planar surface for supporting the foot and a frame receiving portion opposite the foot receiving portion. The frame may include an overmolding layer extending from a side of the frame opposite the midsole so as to form a ground contacting surface. The overmolding layer may have a non-uniform density. The sole assembly may be secured to the frame by a self-locking fit between the sole assembly and the frame.
