Aziz, Nazneen,Cole, Geoffrey,Hedley, Mary Lynne,Tomlinson, Andrew J.,Urban, Robert G.
申请号：
AU2012204129
公开号：
AU2012204129A8
申请日:
2012.07.12
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012204129A820120830.pdf#####ABSTRACT The present invention provides nucleic acids containing transcriptional units that encode 5 CYP I B I polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the untranslated region (UTR) of naturally occurring forms of the CYPIBI transcript. Then nucleic acids of the invention lack translational repressor elements and thus provide for a system of enhanced translation of the CYP1B1 polypeptide or portions thereof. Also disclosed are methods of administering nucleic acids to a mammal and use 10 in the treatment of proliferative disorders or cancer.
