COMPOSÉ MONOMÈRE D'ACIDE NUCLÉIQUE MODIFIÉ ET ANALOGUE D'ACIDE OLIGONUCLÉIQUE

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专利权人:

Eisai R&D Management Co.; Ltd.

发明人:

申请号：

EP18817223.3

公开号：

EP3643706A9

申请日:

2018.06.14

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present invention provides a modified nucleic acid monomer compound having a specific backbone such as 2-ethylglycerol or methoxymethyl-1,3-propanediol backbone instead of a ribose or deoxyribose backbone of a nucleoside, and an oligonucleic acid analogue containing the monomer compound as at least one of building blocks. The oligonucleic acid analogue containing the nucleic acid monomer compound of the present invention allows provision of an oligonucleic acid analogue having excellent biological stability and/or target gene silencing activity.

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