The invention relates to a detection device for the in vivo and/or in vitroenrichment of samplematerial, comprising a functional surface charged with detection receptors. Toensure thediagnosis of different diseases using a detection device of the type mentionedat the outset withless efforts and an improved precision of the diagnosis, it is providedaccording to the inventionthat the detection device comprises at least one guide element and at leasttwo functionalelements disposed at the guide element, wherein a functional surface chargedwith detectionreceptors is formed at each of them, the functional elements being designedfor beingdetachable from each other and/or individually detachable from the guideelement. Furthermore,the invention provides a use of and a method for the application of saiddetection device.