A method to manage flushing of a catheter assembly a clamp configured to clamp an extension tube of a catheter assembly. The clamp may include an acoustic sensor configured to detect fluid flowing through the extension tube. The clamp and the acoustic sensor may be disposed outside of the extension tube. The clamp may include a pinch clamp or a non-pinch clamp. The acoustic sensor may be embedded in the clamp. The method may include detecting, via the acoustic sensor, fluid flowing through the extension tube.
